Heilbronner Lab

Understanding the neurobiology of complex behaviors requires linking diverse methodologies, species, and analytical approaches. The goal of our lab is to use anatomical connectivity and related techniques to help bridge the major divides in neuroscience. Specifically, we perform tract-tracing to understand the neural circuits underpinning motivation and decision-making. We are particularly interested in the medial prefrontal cortex and the posteromedial cortex as critical pieces of the motivation and decision-making circuits. Activations in different portions of these midline regions consistently track subjective value, outcomes, and need for behavioral adjustment. Intriguingly, these areas are also core pieces of the default mode network, a set of highly functionally correlated brain regions consistently deactivated during task performance in humans. A similar network is also present in other species. Thus, the default mode network represents an important circuit for motivation and decision-making that can be interrogated across multiple species.

Specific projects include:

• Leveraging cortical connectivity with conserved subcortical structures to establish circuit-level similarities across species. Ultimately, this process allows us to translate neural results from nonhuman animals to humans, including psychiatric patient populations.
• Mapping posteromedial cortico-basal ganglia pathways to answer fundamental questions about integration within the default mode network and the striatum.
• Anatomically and functionally mapping “patches” of connectivity (small zones of connectivity that do not cover an entire brain region) within the default mode network.
• Establishing patterns of white matter organization to improve targeting of neuromodulatory interventions for psychiatric and neurological disorders.